Lab co-publishes two manuscripts in Clinical Cancer Research

The lab has co-published two manuscripts in Clinical Cancer Research. The first showed that HPV-DeepSeek achieved 99% sensitivity and 99% specificity for diagnosing cancer at the time of first clinical presentation, including for the very earliest stages of disease. This higher accuracy significantly outperforms current standard-of-care methods, including other commercially available liquid biopsy assays. The study is published in Clinical Cancer Research, a journal of the American Association for Cancer Research. In a separate study published in the same issue of Clinical Cancer Research, in collaboration with the lab of Viktor Adalsteinsson at the Broad Institute, the lab tested a different novel assay called MAESTRO in patients with head and neck cancer not caused by HPV to look for evidence of cancer remaining after surgery. Developed at the Broad Institute of MIT and Harvard, this approach improves sensitivity by using a specialized approach to detect genome-wide tumor DNA with minimal sequencing. They found the test could accurately detect residual cancer within a few days of surgery in a highly aggressive form of head and neck cancer and that patients with residual disease detected by the assay had significantly worse survival and recurrence outcomes.

https://www.massgeneralbrigham.org/en/about/newsroom/press-releases/hpv-deepseek-liquid-biopsy-head-and-neck-cancer-screening