As described in a new manuscript published in the journal Cancers, 26% of sinonasal squamous cell carcinomas have detectable HPV. Interestingly, HPV prevalence was higher in subsites with high exposure to secretion flow compared to low exposure subsites and HPV prevalence followed the global distribution of HPV+ oropharyngeal squamous cell carcinoma. This manuscript is the largest analysis of HPV in sinonasal squamous cell carcinoma to date and support a role for HPV in a subset of these cancers.