Faden Laboratory

Publications

2024

Rosing, Fabian; Meier, Matthias; Schroeder, Lea; Laban, Simon; Hoffmann, Thomas; Kaufmann, Andreas; Siefer, Oliver; Wuerdemann, Nora; Klußmann, Jens Peter; Rieckmann, Thorsten; Alt, Yvonne; Faden, Daniel L; Waterboer, Tim; Höfler, Daniela

Quantification of human papillomavirus cell-free DNA from low-volume blood plasma samples by digital PCR Journal Article

In: Microbiol Spectr, pp. e0002424, 2024, ISSN: 2165-0497.

Abstract | Links | BibTeX

Naegele, Saskia; Das, Dipon; Hirayama, Shun; Shalhout, Sophia Z; Lee, Hang; Richmon, Jeremy D; Faden, Daniel L

Circulating Tumor HPV DNA in Patients With Stage I and II HPV-Associated Head and Neck Cancer After Surgery Journal Article

In: JAMA Otolaryngol Head Neck Surg, vol. 150, no. 6, pp. 521–523, 2024, ISSN: 2168-619X.

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Lewis, James S; Naegele, Saskia; Efthymiou, Vasileios; Mehrad, Mitra; Ely, Kim A; Waterboer, Tim; Kuhs, Krystle A Lang; Davis, Seth J; Richard, Kelsey; Das, Dipon; Faden, Daniel L

Assessing the feasibility of a multimodal liquid biopsy for the diagnosis of HPV-associated oropharyngeal squamous cell carcinoma Journal Article

In: Am J Clin Pathol, vol. 161, no. 6, pp. 570–578, 2024, ISSN: 1943-7722.

Abstract | Links | BibTeX

Ruiz-Torres, Daniel A; Naegele, Saskia; Podury, Archana; Wirth, Lori; Shalhout, Sophia Z; Faden, Daniel L

Immunotherapy time of infusion impacts survival in head and neck cancer: A propensity score matched analysis Journal Article

In: Oral Oncol, vol. 151, pp. 106761, 2024, ISSN: 1879-0593.

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Das, Dipon; Hirayama, Shun; Aye, Ling; Bryan, Michael E; Naegele, Saskia; Zhao, Brian; Efthymiou, Vasileios; Mendel, Julia; Fisch, Adam S; Kröller, Lea; Michels, Birgitta E; Waterboer, Tim; Richmon, Jeremy D; Adalsteinsson, Viktor; Lawrence, Michael S; Crowson, Matthew G; Iafrate, A John; Faden, Daniel L

Blood-based screening for HPV-associated cancers Journal Article Forthcoming

In: medRxiv, Forthcoming.

BibTeX

Efthymiou, Vasileios; Queenan, Natalia; Haas, Markus; Naegele, Saskia; Goss, Deborah; Faden, Daniel L

Circulating Tumor DNA in the Immediate Postoperative Setting Journal Article

In: Ann Surg Oncol, 2024, ISSN: 1534-4681.

Abstract | Links | BibTeX

2023

Kentnowski, Marek; Cortez, Alexander J; Mazurek, Agnieszka M; Mrochem-Kwarciak, Jolanta; Hebda, Anna; Kacorzyk, Urszula; Drosik-Rutowicz, Katarzyna; Chmielik, Ewa; Paul, Piotr; Gajda, Karolina; Łasińska, Izabela; Bobek-Billewicz, Barbara; d’Amico, Andrea; Składowski, Krzysztof; Śnietura, Mirosław; Faden, Daniel L; Rutkowski, Tomasz W

Determinants of the level of circulating-tumor HPV16 DNA in patients with HPV-associated oropharyngeal cancer at the time of diagnosis Journal Article

In: Sci Rep, vol. 13, no. 1, pp. 21226, 2023, ISSN: 2045-2322.

Abstract | Links | BibTeX

Naegele, Saskia; Ruiz-Torres, Daniel A; Zhao, Yan; Goss, Deborah; Faden, Daniel L

Comparing the Diagnostic Performance of qPCR, ddPCR, and NGS Liquid Biopsies for HPV-Associated Cancers Journal Article

In: J Mol Diagn, 2023, ISSN: 1943-7811.

Abstract | Links | BibTeX

Bloom, Jacob C; Kaufmann, Nicole; Koss, Shirley; Edwards, Heather A; Perkins, Rebecca B; Faden, Daniel L

Deciphering Knowledge and Opinions of Human Papillomavirus and Human Papillomavirus Vaccination for Facilitation of Point-of-Care Vaccination in Adults Journal Article

In: JAMA Otolaryngol Head Neck Surg, vol. 149, no. 10, pp. 870–877, 2023, ISSN: 2168-619X.

Abstract | Links | BibTeX

Zhao, Brian Y; Naegele, Saskia; Efthymiou, Vasileios; Hirayama, Shun; Mendel, Julia; Lin, Derrick T; Das, Dipon; Faden, Daniel L

Atypical metastases highlight the true potential of ctDNA liquid biopsies for cancer monitoring Journal Article

In: Oral Oncol, vol. 144, pp. 106464, 2023, ISSN: 1879-0593.

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Rettig, Eleni M; Waterboer, Tim; Sim, Edward; Faden, Daniel L; Butt, Julia; Hanna, Glenn J; Fitz, Catherine Del Vecchio; Kuperwasser, Charlotte; Sroussi, Herve

Relationship of HPV16 E6 seropositivity with circulating tumor tissue modified HPV16 DNA before head and neck cancer diagnosis Journal Article

In: Oral Oncol, vol. 141, pp. 106417, 2023, ISSN: 1879-0593.

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Naegele, Saskia; Efthymiou, Vasileios; Hirayama, Shun; Zhao, Brian Y; Das, Dipon; Chan, Annie W; Richmon, Jeremy D; Iafrate, A John; Faden, Daniel L

Double trouble: Synchronous and metachronous primaries confound ctHPVDNA monitoring Journal Article

In: Head Neck, vol. 45, no. 6, pp. E25–E30, 2023, ISSN: 1097-0347.

Abstract | Links | BibTeX

Naegele, Saskia; Efthymiou, Vasileios; Das, Dipon; Sadow, Peter M; Richmon, Jeremy D; Iafrate, A John; Faden, Daniel L

Detection and Monitoring of Circulating Tumor HPV DNA in HPV-Associated Sinonasal and Nasopharyngeal Cancers Journal Article

In: JAMA Otolaryngol Head Neck Surg, vol. 149, no. 2, pp. 179–181, 2023, ISSN: 2168-619X.

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Miller, Lauren E; Au, Vivienne H; Sivarajah, Shanmugappiriya; Lin, Derrick T; Deschler, Daniel G; Varvares, Mark A; Faden, Daniel L; Feng, Allen L; Sadow, Peter M; Richmon, Jeremy D

Rate of atypical nodal metastases in surgically treated HPV-associated oropharyngeal squamous cell carcinoma Journal Article

In: Head Neck, vol. 45, no. 2, pp. 409–416, 2023, ISSN: 1097-0347.

Abstract | Links | BibTeX

2022

Lin, Maoxuan; Sade-Feldman, Moshe; Wirth, Lori; Lawrence, Michael S; Faden, Daniel L

Single-cell transcriptomic profiling for inferring tumor origin and mechanisms of therapeutic resistance Journal Article

In: NPJ Precis Oncol, vol. 6, no. 1, pp. 71, 2022, ISSN: 2397-768X.

Abstract | Links | BibTeX

Rettig, Eleni M; Faden, Daniel L; Sandhu, Shaiba; Wong, Kristine; Faquin, William C; Warinner, Chloe; Stephens, Phil; Kumar, Sunil; Kuperwasser, Charlotte; Richmon, Jeremy D; Uppaluri, Ravindra; Varvares, Mark; Sethi, Rosh; Hanna, Glenn J; Sroussi, Herve

Detection of circulating tumor human papillomavirus DNA before diagnosis of HPV-positive head and neck cancer Journal Article

In: Int J Cancer, vol. 151, no. 7, pp. 1081–1085, 2022, ISSN: 1097-0215.

Abstract | Links | BibTeX

Haas, Markus; Hansen, Elisabeth E; Lewis, James S; Faden, Daniel L

Is it Time for a Molecular-based Classification System for Sinonasal Squamous Cell Carcinoma? Journal Article

In: Am J Surg Pathol, vol. 46, no. 7, pp. 873–877, 2022, ISSN: 1532-0979.

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Kuhs, K A Lang; Faden, D L; Chen, L; Smith, D K; Pinheiro, M; Wood, C B; Davis, S; Yeager, M; Boland, J F; Cullen, M; Steinberg, M; Bass, S; Wang, X; Liu, P; Mehrad, M; Tucker, T; Lewis, J S; Ferris, R L; Mirabello, L

Genetic variation within the human papillomavirus type 16 genome is associated with oropharyngeal cancer prognosis Journal Article

In: Ann Oncol, vol. 33, no. 6, pp. 638–648, 2022, ISSN: 1569-8041.

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O'Boyle, Connor J; Siravegna, Giulia; Varmeh, Shohreh; Queenan, Natalia; Michel, Alexa; Pang, Kim Chang Sing; Stein, Jarrod; Thierauf, Julia C; Sadow, Peter M; Faquin, William C; Wang, Wei; Deschler, Daniel G; Emerick, Kevin S; Varvares, Mark A; Park, Jong C; Clark, John R; Chan, Annie W; Busse, Paul M; Corcoran, Ryan B; Wirth, Lori J; Lin, Derrick T; Iafrate, A John; Richmon, Jeremy D; Faden, Daniel L

Cell-free human papillomavirus DNA kinetics after surgery for human papillomavirus-associated oropharyngeal cancer Journal Article

In: Cancer, vol. 128, no. 11, pp. 2193–2204, 2022, ISSN: 1097-0142.

Abstract | Links | BibTeX

Siravegna, Giulia; O'Boyle, Connor J; Varmeh, Shohreh; Queenan, Natalia; Michel, Alexa; Stein, Jarrod; Thierauf, Julia; Sadow, Peter M; Faquin, William C; Perry, Simon K; Bard, Adam Z; Wang, Wei; Deschler, Daniel G; Emerick, Kevin S; Varvares, Mark A; Park, Jong C; Clark, John R; Chan, Annie W; Arasa, Vanessa Carlota Andreu; Sakai, Osamu; Lennerz, Jochen; Corcoran, Ryan B; Wirth, Lori J; Lin, Derrick T; Iafrate, A John; Richmon, Jeremy D; Faden, Daniel L

Cell-Free HPV DNA Provides an Accurate and Rapid Diagnosis of HPV-Associated Head and Neck Cancer Journal Article

In: Clin Cancer Res, vol. 28, no. 4, pp. 719–727, 2022, ISSN: 1557-3265.

Abstract | Links | BibTeX

Faden, Daniel L

Liquid biopsy for the diagnosis of HPV-associated head and neck cancer Journal Article

In: Cancer Cytopathol, vol. 130, no. 1, pp. 12–15, 2022, ISSN: 1934-6638.

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2021

Lewis, James S; Mirabello, Lisa; Liu, Ping; Wang, Xiaowei; Dupont, William D; Plummer, W Dale; Pinheiro, Maisa; Yeager, Meredith; Boland, Joseph F; Cullen, Michael; Steinberg, Mia; Bass, Sara; Mehrad, Mitra; O'Boyle, Connor; Lin, Maoxuan; Faden, Daniel L; Lang-Kuhs, Krystle A

Oropharyngeal Squamous Cell Carcinoma Morphology and Subtypes by Human Papillomavirus Type and by 16 Lineages and Sublineages Journal Article

In: Head Neck Pathol, vol. 15, no. 4, pp. 1089–1098, 2021, ISSN: 1936-0568.

Abstract | Links | BibTeX

Vyas, Avani; Harbison, R Alex; Faden, Daniel L; Kubik, Mark; Palmer, Drake; Zhang, Qing; Osmanbeyoglu, Hatice U; Kiselyov, Kirill; Méndez, Eduardo; Duvvuri, Umamaheswar

Recurrent Human Papillomavirus-Related Head and Neck Cancer Undergoes Metabolic Reprogramming and Is Driven by Oxidative Phosphorylation Journal Article

In: Clin Cancer Res, vol. 27, no. 22, pp. 6250–6264, 2021, ISSN: 1557-3265.

Abstract | Links | BibTeX

Faden, Daniel L; Kuhs, Krystle A Lang; Lin, Maoxuan; Langenbucher, Adam; Pinheiro, Maisa; Yeager, Meredith; Cullen, Michael; Boland, Joseph F; Steinberg, Mia; Bass, Sara; Lewis, James S; Lawrence, Michael S; Ferris, Robert L; Mirabello, Lisa

APOBEC Mutagenesis Is Concordant between Tumor and Viral Genomes in HPV-Positive Head and Neck Squamous Cell Carcinoma Journal Article

In: Viruses, vol. 13, no. 8, 2021, ISSN: 1999-4915.

Abstract | Links | BibTeX

Faden, Daniel L; O'Boyle, Connor J; Lin, Derrick T; Deschler, Daniel G; Emerick, Kevin S; Varvares, Mark A; Faquin, William C; Sadow, Peter M; Richmon, Jeremy D

Prospective assessment of multiple HPV-positive oropharyngeal squamous cell carcinomas Journal Article

In: Oral Oncol, vol. 117, pp. 105212, 2021, ISSN: 1879-0593.

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Faden, Daniel L; Langenbucher, Adam; Kuhs, Krystle; Lewis, James S; Mirabello, Lisa; Yeager, Meredith; Boland, Joseph F; Bass, Sara; Steinberg, Mia; Cullen, Michael; Lawrence, Michael S; Ferris, Robert L

HPV+ oropharyngeal squamous cell carcinomas from patients with two tumors display synchrony of viral genomes yet discordant mutational profiles and signatures Journal Article

In: Carcinogenesis, vol. 42, no. 1, pp. 14–20, 2021, ISSN: 1460-2180.

Abstract | Links | BibTeX

Campbell, Benjamin R; Chen, Zhishan; Faden, Daniel L; Agrawal, Nishant; Li, Ryan J; Hanna, Glenn J; Iyer, N Gopalakrishna; Boot, Arnoud; Rozen, Steven G; Vettore, Andre L; Panda, Binay; Krishnan, Neeraja M; Pickering, Curtis R; Myers, Jeffrey N; Guo, Xingyi; Kuhs, Krystle A Lang

The mutational landscape of early- and typical-onset oral tongue squamous cell carcinoma Journal Article

In: Cancer, vol. 127, no. 4, pp. 544–553, 2021, ISSN: 1097-0142.

Abstract | Links | BibTeX

2020

Pang, Kim J W Chang Sing; Mur, Taha; Collins, Louise; Rao, Sowmya R; Faden, Daniel L

Human Papillomavirus in Sinonasal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis Journal Article

In: Cancers (Basel), vol. 13, no. 1, 2020, ISSN: 2072-6694.

Abstract | Links | BibTeX

Park, Jong Chul; Durbeck, Julia; Clark, John R; Faden, Daniel L

Treatment sequence of cetuximab and immune checkpoint inhibitor in head and neck squamous cell carcinoma differentially affects outcomes Journal Article

In: Oral Oncol, vol. 111, pp. 105024, 2020, ISSN: 1879-0593.

Abstract | Links | BibTeX

Park, Jong Chul; Faquin, William C; Durbeck, Julia; Faden, Daniel L

Immune checkpoint inhibitors in sinonasal squamous cell carcinoma Journal Article

In: Oral Oncol, vol. 109, pp. 104776, 2020, ISSN: 1879-0593.

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Elgart, Katya; Faden, Daniel L

Sinonasal Squamous Cell Carcinoma: Etiology, Pathogenesis, and the Role of Human Papilloma Virus Journal Article

In: Curr Otorhinolaryngol Rep, vol. 8, no. 2, pp. 111–119, 2020, ISSN: 2167-583X.

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Strober, William; Shishido, Sachie; Wood, Burton; Lewis, James S; Kuhs, Krystle; Ferris, Robert L; Faden, Daniel L

Two for the price of one: Prevalence, demographics and treatment implications of multiple HPV mediated Head and Neck Cancers Journal Article

In: Oral Oncol, vol. 100, pp. 104475, 2020, ISSN: 1879-0593.

Abstract | Links | BibTeX